CBD for Epilepsy

The cause of epilepsy is unknown but researchers think it might be due to:

• Stroke
• Insufficient oxygen at birth
• Head injuries
• Inadequate blood sugar and sodium
• Brain tumors
• Brain injuries
• Family tendency

How does CBD stop seizures?

As early as the 1970s, researchers came to the conclusion¹  that cannabidiol had anticonvulsant properties. Anticonvulsants (also called antiepileptics) are used against epileptic seizures. About one third of epilepsy patients have a so-called treatment-resistant form. A study² published in 2013 in the journal “Epilepsy & Behavior” examined the effects of CBD-enriched medical cannabis in children with treatment-resistant epilepsy. Out of 19 participants, 13 had Dravet syndrome, 4 had Doose syndrome and one child each suffered from Lennox-Gastaut syndrome and idiopathic epilepsy.

As a result, 16 of the 19 participants (84%) reported a decrease in seizures, two of which were even seizure-free. Positive side effects were improved mood and sleep. In particular the sleep quality with Doose syndrome patients could be positively affected by CBD. Another study also suggests CBD as a treatment for night snoring³

Results of the study by Porter, Brenda E., and Catherine Jacobson :

	Diagnosis	Age	Duration of CBD intake	CBD (mg/ kg/ day)	THC (mg/ kg/ day)	Attacks before CBD	Attacks while using CBD	Medications discontinued during CBD intake
1	Lennox-Gastaut	7 ♀	>1 year	?	?	>100 per day	8-10 per day	Banzel, Onfi
2	Dravet	14 ♀	>4 months	14	0.5	5 per day	0-1 per day
3	EFMR	12 ♀	2-4 months	7	0.5	12 per day	0-1 per day
4	Dravet	7 ♂	>4 months	8	0.25-0.5	50 per week	50 per week
5	Dravet	6 ♀	>4 months	4	0.1-0.25	200-300 per week	0-2 per week	Onfi
6	Dravet	16 ♀	>4 months	1-2	0.02-0.1	7 per week	4 per week	Onfi
7	Dravet	13 ♂	3-4 months	4	0.02-0.1	40 per week	30 per week	Phenobarbital, Depakote
8	Dravet		>4 months	?	?	3 per week	1-2 per week	Klonopin
9	Dravet	♂	>4 months	3-4	0.04-0.2	100-500 per week	1-2 per week	STP, Topamax, Depakote
10	Dravet		>4 months	4	0.2-0.4	200-300 per week	20-50 per week	STP
11	Dravet	8 ♀	>1 year	?	?	5-10 per week	0-3 per week	STP, Onfi, Depakote
12	Dravet	7 ♀	>4 months	3-4	0.04-0.2	>20 per week	0-10 per week	Ongi, Zonegran, Depakote
13	Doose	9 ♀	>4 months	10-13	0.5	60-250 per day	0	Lorazepam, Ethosuximide
14	Dravet	2 ♂	>4 months	7	0.08-0.4	2 per week	0
15	Doose		2 weeks	<0.5	0.01-0.05	1-7 per week	1-7 per week
16	Doose	11 ♂	1-2 months	6	0.6-0.8	20 per week	4 per week
17	Doose		1-2 months	6	0	15-20 per day	0-3 per day	Steroids
18	Idiopathic	♀	<1 month	28	0.5-0.7	10 per week	8 per week	Valproic acid
19	Dravet	6 ♀	>4 months	1	0.06-0.3	3 per week	3 per week

During the time CBD was taken, patients stopped taking Banzel, Onfi, Phenobarbital, Depakote, Klonipin, STP, Topamax, Zonegran, Lorazepam, Ethosuximide, Steroids and Valproic Acid. Please always consult a doctor before discontinuing any medication. The CBD doses in the study are sometimes extremely high. Hemppedia also explicitly does not recommend the use of CBD products in children.

What are the benefits of using CBD to treat Epilepsy?

There are a number of benefits that could result from the use of CBD for the treatment of epilepsy. A number of studies by Karler et.al¹, Porter et.al², Devinksky, Orrin et.al.⁴ as well as Cunha et.al⁵ among others, have come to this conclusion.

These advantages include the following:

It’s All Natural with no major side-effects

CBD can be supportive in the treatment of epilepsy, as investigated by Devinsky et al. 2014. No dangerous side effects were observed in macro-doses up to 1500 mg/day⁴. Side effects in the study by Porter, Brenda E., and Catherine Jacobson included increased fatigue in some children⁶.

For more detailed information about the side-effects of CBD, please read our CBD oil side-effects guide.

Ability to Interact with Brain Receptors

Brain receptors play an important role in the treatment of seizures. When someone suffers from neuroglial disorders, the brain is unable to control mood, appetite, movement, emotions, coordination and inflammation, leading to seizures. Labra et al. concluded in 2018 that cannabinoids have a role in regulating the opening of the hemichannels, which play a key role⁷

It’s Less Expensive

The use of CBD oil is less expensive compared to other epileptic treatment plans. Therefore, a lot of epileptic individuals can gain access to these CBD oils at affordable prices. However, its cheap price tends to raise eyebrows. As a result, some people might have second thoughts concerning their capabilities.

Strengthens the Endocannabinoid System

A strong and efficient ECS system strengthens the body immunity⁸. Hence the body can treat, heal and fight health diseases and conditions inclusive of epilepsy. CBD offers your body that much needed strong ECS system.

What are the side effects of using CBD to treat Epilepsy?

Just like with any other medicine, CBD has certain side effects that we need to be aware of⁹ The patients can feel the conditions like:

• Drowsiness
• Low blood pressure
• Dry mouth

All these conditions are happening after the first usage of CBD oil, and some of them are associated with other medical conditions. If you are prone to other diseases, you may consult the doctor before using the CBD oil.

CBD Dosage for Epilepsy

Dosage is course different for each patient and should be monitored. It is best to consult your doctor for a more accurate assessment.

Based on the guide in the book by Leinow & Birnbaum  “CBD: A patient’s guide to Medical Cannabis”¹⁰ we recommend the Step-Up method to find out the ideal dosage. Leinow & Birnbaum recommend to start with a microdose for epilepsy

To find out more about the microdose and how to take it, read our article on CBD dosing.

Disclaimer: For legal reasons, we at Hemppedia are not allowed to make any specific recommendation to use CBD products for children.

Success stories of people using CBD to treat Epilepsy

There have been a number of success stories about positive results from patients who have used CBD to treat Epilepsy. Some of the stories have gone a long way to gain media coverage. For instance:

• How CBD helps with epilepsy

• CBD is also used for animals such as dogs with seizures and muscle cramps, as you can see in this video with a dog.

Historical Research on CBD for Epilepsy

Various studies have been conducted to confirm the role played by CBD in treating epilepsy. These studies have paid off since significant findings were made. They include the following;

• In 2,700 BC archeological excavations unearthed an old grave that contained a large amount of cannabis. It had been preserved and presumably used as a medicinal agent for treating various diseases including epilepsy¹¹
• Anti-seizure medication description was published in 1843 by W. B O’Shaughnessy, a competent physician. This publication confirmed anti-seizure properties in Cannabis¹².

In Summary

Epilepsy involves having recurring and unprovoked seizures. They can occur at any time, thus risking the epileptic individual. However, the inception of CBD oil has done enough good for these patients. CBD has anticonvulsant properties that efficiently reduces the number of seizures. Besides, it alleviates the symptoms that come with epilepsy. As an epileptic patient, you can give it a try. You should experience results, but also be aware that more research is needed.

References

1. Karler, Ralph, William Cely, and Stuart A. Turkanis. „The anticonvulsant activity of cannabidiol and cannabinol.“ Life Sciences 13.11 (1973): 1527-1531. [↩] [↩]
2. Porter, Brenda E., and Catherine Jacobson. „Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.“ Epilepsy & Behavior 29.3 (2013): 574-577. [↩] [↩]
3. Guy, Geoffrey, et al. „Use of cannabidiol in the treatment of nocturnal snoring.“ U.S. Patent Application No. 15/519,244. [↩]
4. Devinsky, Orrin, et al. „Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.“ Epilepsia 55.6 (2014): 791-802. [↩] [↩]
5. Cunha, Jomar M., et al. „Chronic administration of cannabidiol to healthy volunteers and epileptic patients.“ Pharmacology 21.3 (1980): 175-185 [↩]
6. orter, Brenda E., and Catherine Jacobson. „Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.“ Epilepsy & Behavior 29.3 (2013): 574-577. [↩]
7. Labra, Valeria C., et al. „The neuroglial dialog between cannabinoids and hemichannels.“ Frontiers in molecular neuroscience 11 (2018): 79. [↩]
8. Perucca, Emilio. „Cannabinoids in the treatment of epilepsy: hard evidence at last?.“ Journal of epilepsy research 7.2 (2017): 61. [↩]
9. Iffland, K. and Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and Cannabinoid Research, 2(1), pp.139-154. [↩]
10. Leinow,, L. and Birnbaum, J. (2017). CBD: A Patient’s Guide to Medicinal Cannabis. North Atlantic Books. [↩]
11. Perucca, Emilio. „Cannabinoids in the treatment of epilepsy: hard evidence at last?.“ Journal of epilepsy research 7.2 (2017): 61. [↩]
12. loss, David, and Barbara Vickrey. „Cannabinoids for epilepsy.“ Cochrane database of systematic reviews 3 (2014). [↩]